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Article

Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease.

Brain research. Developmental brain research - 28 Feb 2002

Visser Jasper E, Smith Doug W, Moy Sheryl S, Breese George R, Friedmann Theodore, Rothstein Jeffrey D, Jinnah H A

Abstract excerpt

Lesch-Nyhan disease, a neurogenetic disorder caused by congenital deficiency of the purine salvage enzyme hypoxanthine guanine phosphoribosyl transferase, is associated with a prominent loss of striatal dopamine. The current studies address the hypothesis that oxidant stress causes damage or dysfunction of nigrostriatal dopamine neurons in a knockout mouse model of the disease, by assessing several markers of...

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PMID: 11882343
DOI: 10.1016/s0165-3806(02)00280-8

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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