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Article

Influence of Age and Strain on Striatal Dopamine Loss in a Genetic Mouse Model of Lesch‐Nyhan Disease

1 Jan 1999

Abstract excerpt

Lesch-Nyhan disease is a neurogenetic disorder caused by deficiency of the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT). Affected individuals exhibit a characteristic pattern of neurological and behavioral features attributable in part to dysfunction of basal ganglia dopamine systems. In the current studies, striatal dopamine loss was investigated in five different HPRT-deficient...

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Identifiers

PMID: 9886073
DOI: 10.1046/j.1471-4159.1999.0720225.x

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Source receipt: pubmed, retrieved 7 Sept 2026.

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