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Article

Comparison of camptothecin derivatives presently in clinical trials: genotoxic potency and mitotic recombination.

Mutagenesis - 1 Mar 2002

Cunha Kênya Silva, Reguly Maria Luíza, Graf Ulrich, Rodrigues de Andrade Heloisa Helena

Abstract excerpt

The genotoxicity of camptothecin (CPT) and its clinical antineoplastic analogues irinotecan (CPT-11) and topotecan (TPT) were evaluated using the wing somatic mutation and recombination test (SMART) in Drosophila melanogaster. These compounds stabilize and trap the topoisomerase I-DNA complex, preventing the religation step of the breakage/rejoining reaction mediated by the enzyme. The standard version of the...

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PMID: 11880543
DOI: 10.1093/mutage/17.2.141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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