Article
Comparative analysis of genetic toxicity of AZT and ddI antiretrovirals in somatic cells of Drosophila melanogaster.
Environmental and molecular mutagenesis - 1 May 2008
Guimarães Nilza Nascimento, de Castro Pereira Karla, de Andrade Heloísa Helena Rodrigues, Lehmann Maurício, Silva Cunha Kênya
Abstract excerpt
Antiretroviral therapies based on nucleoside reverse transcriptase inhibitors, like zidovudine (3'-azido-3'-deoxythymidine; AZT) and didanosine (2',3'-dideoxyinosine; ddI), markedly reduce human immunodeficiency virus loads. The Somatic Mutation And Recombination Test in Drosophila melanogaster (wing SMART), in its standard version, was applied to compare AZT and ddI genetic toxicity expressed as point and...
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