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Article

Proteolipid protein gene modulates viability and phenotype of neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Mar 2002

Boucher Shayne E M, Cypher Maria A, Carlock Leon R, Skoff Robert P

Abstract excerpt

Overexpression or lack of expression of proteolipid protein (PLP) gene by oligodendrocytes causes axonal pathology. It is unclear whether dysfunction of the PLP gene mediates its effects directly on neurons or indirectly by abnormal formation of myelin sheaths. We performed experiments using cocultures and conditioned media (CM) to test the direct effect of PLP gene expression on neurons. Non-glial cell lines...

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Identifiers

PMID: 11880506
PMCID: PMC6758887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Proteolipid protein gene modulates viability and phenotype of neurons.PMID 11880506Read ↗

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