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Article

CD40 is expressed and functional on neuronal cells.

The EMBO journal - 15 Feb 2002

Tan Jun, Town Terrence, Mori Takashi, Obregon Demian, Wu Yajuan, DelleDonne Anthony, Rojiani Amyn, Crawford Fiona, Flavell Richard A, Mullan Mike

Abstract excerpt

We show here that CD40 mRNA and protein are expressed by neuronal cells, and are increased in differentiated versus undifferentiated N2a and PC12 cells as measured by RT-PCR, western blotting and immunofluorescence staining. Additionally, immunohistochemistry reveals that neurons from adult mouse and human brain also express CD40 in situ. CD40 ligation results in a time-dependent increase in p44/42 MAPK...

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Identifiers

PMID: 11847112
DOI: 10.1093/emboj/21.4.643
PMCID: PMC125862

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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