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Article

Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

Blood - 15 Sept 1999

Hamblin T J, Davis Z, Gardiner A, Oscier D G, Stevenson F K

Abstract excerpt

Despite having several characteristics of naïve B cells, chronic lymphocytic leukemia (CLL) cells have been shown in some cases to have somatically mutated Ig variable region genes, indicating that the cell of origin has passed through the germinal center. A previous study of patients with CLL found an association between lack of somatic mutation and trisomy 12 and, therefore, possibly with a less favorable...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10477713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.PMID 10477713Read ↗

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