Article
Genetic risk determines the emergence of diabetes-associated autoantibodies in young children.
Diabetes - 1 Mar 2002
Kupila Antti, Keskinen Päivi, Simell Tuula, Erkkilä Satu, Arvilommi Paula, Korhonen Sari, Kimpimäki Teija, Sjöroos Minna, Ronkainen Matti, Ilonen Jorma, Knip Mikael, Simell Olli
Abstract excerpt
Timing of onset of autoimmunity is a prerequisite for unmasking triggers and pathogenesis of type 1 diabetes. We followed 4,590 consecutive newborns with 8 or 3% HLA-DQB1 conferred risk for type 1 diabetes at 3-, 6-, or 12-month intervals up to 5.5 years of age. Islet cell autoantibodies (ICAs) and, in the 137 children with ICAs, insulin autoantibodies (IAAs), GAD65 autoantibodies (GADAs), and IA-2 protein...
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