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Article

Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study.

Diabetes care - 1 Sept 2017

Krischer Jeffrey P, Lynch Kristian F, Lernmark Åke, Hagopian William A, Rewers Marian J, She Jin-Xiong, Toppari Jorma, Ziegler Anette-G, Akolkar Beena

Abstract excerpt

OBJECTIVE: We tested the associations between genetic background and selected environmental exposures with respect to islet autoantibodies and type 1 diabetes. RESEARCH DESIGN AND METHODS: Infants with HLA-DR high-risk genotypes were prospectively followed for diabetes-related autoantibodies. Single nucleotide polymorphisms (SNPs) came from the Illumina ImmunoChip and environmental exposure data were by parental...

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Share to Diabetes Mellitus, Type 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Source

Open in PubMed Open full text

Identifiers

PMID: 28646072
DOI: 10.2337/dc17-0238
PMCID: PMC5566280

Genes

BACH2
ERBB3
INS
PTPN22

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Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study.PMID 28646072Read ↗

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study.Semantic proximity Read ↗

Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY).Semantic proximity Read ↗

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Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study.Semantic proximity Read ↗

The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History on the Progression From Multiple Autoantibodies to Type 1 Diabetes: A TEDDY Study Report.Semantic proximity Read ↗

Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease.Semantic proximity Read ↗

Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study.Semantic proximity Read ↗

Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress ReportSemantic proximity Read ↗

The Environmental Determinants of Diabetes in the Young (TEDDY) Study.Semantic proximity Read ↗

Genetic risk determines the emergence of diabetes-associated autoantibodies in young children.Semantic proximity Read ↗

Autoimmune Diabetes From Childhood to Adulthood: The Role of Pancreatic Autoantibodies and HLA-DRB1 Genotype.Semantic proximity Read ↗

Family history of type 2 diabetes delays development of type 1 diabetes in TEDDY children with islet autoimmunity.Semantic proximity Read ↗

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