Article
Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents.
Annals of internal medicine - 1 Jun 2004
Hummel Michael, Bonifacio Ezio, Schmid Sandra, Walter Markus, Knopff Annette, Ziegler Anette-G
Abstract excerpt
BACKGROUND: The development of type 1 diabetes mellitus is preceded by autoimmunity against islet beta cells. OBJECTIVE: To determine the risk for islet autoimmunity and childhood diabetes in offspring of affected parents. DESIGN: Prospective cohort study. SETTING: German BABYDIAB study. PARTICIPANTS: 1610 offspring of parents with type 1 diabetes. MEASUREMENTS: Autoantibodies to islet autoantigens were measured...
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