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Article

Familial clustering of beta-cell autoimmunity in initially non-diabetic children.

Diabetes/metabolism research and reviews - 1 Jan 2000

Kukko Marika, Toivonen Anna, Kupila Antti, Korhonen Sari, Keskinen Päivi, Veijola Riitta, Virtanen Suvi M, Ilonen Jorma, Simell Olli, Knip Mikael

Abstract excerpt

BACKGROUND: Type 1 diabetes is characterised by familial aggregation. We set out to explore whether beta-cell autoimmunity, which is considered to precede clinical disease, also shows familial clustering. METHODS: Tests for HLA DQB1 alleles (*02, *0301, *0302, *0602) and islet cell autoantibodies (ICA) were performed on 5836 children from 2283 families. When a child tested positive for ICA, all his/her previous...

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Identifiers

PMID: 16100734
DOI: 10.1002/dmrr.584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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