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Article

Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation.

Brain : a journal of neurology - 1 Mar 2002

Garbern James Y, Yool Donald A, Moore Gregory J, Wilds Ian B, Faulk Michael W, Klugmann Matthias, Nave Klaus-Amin, Sistermans Erik A, van der Knaap Marjo S, Bird Thomas D, Shy Michael E, Kamholz John A, Griffiths Ian R

Abstract excerpt

Axonal degeneration contributes to clinical disability in the acquired demyelinating disease multiple sclerosis. Axonal degeneration occurs during acute attacks, associated with inflammation, and during the chronic progressive phase of the disease in which inflammation is not prominent. To explore the importance of interactions between oligodendrocytes and axons in the CNS, we analysed the brains of rodents and...

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Identifiers

PMID: 11872612
DOI: 10.1093/brain/awf043

Genes

PLP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation.PMID 11872612Read ↗

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Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination.Semantic proximity Read ↗

Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice.Semantic proximity Read ↗

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