Article

Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed myelinating oligodendrocytes in <i>PLP1</i> mutant mice

2023-01-10

Abstract excerpt

<h4>Summary</h4> Myelin defects lead to neurological dysfunction in various diseases and in normal aging. Chronic neuroinflammation often contributes to axon-myelin damage in these conditions and can be initiated and/or sustained by perturbed myelinating glia. We have previously shown that distinct mutations in the PLP1 gene result in neurodegeneration that is largely driven by adaptive immune cells. Here we cha...

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Literature Corpus work: 74c1682f-d815-5da2-a965-9ef1f96d9d1c
DOI: 10.1101/2023.01.10.523231

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