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Article

Cell growth- and P53-dependent transcriptional activity of the midkine promoter confers suicide gene expression in tumor cells.

Oncology reports - 1 Jan 2000

Yu Ling, Ugai Shin-Ichi, O-Wang Jiyang, Namba Masayoshi, Kadomatsu Kenji, Muramatsu Takashi, Matsubara Shuichiro, Sakiyama Shigeru, Tagawa Masatoshi

Abstract excerpt

Midkine (MK) is preferentially expressed in a number of human tumors, while the expression in adult normal tissues is restricted. Previous studies showed that a 2.3-kb regulatory region of the human MK gene could selectively activate a linked suicide gene in tumors. In this study, we explored the minimal promoter region using genomic fragments deleted from the 5'-upstream side and analyzed the mechanism of the...

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PMID: 12883697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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