12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mice expressing epidermal-targeted v-fos induces rasHA-activated papillomas and carcinomas without p53 mutation: association of v-fos expression with promotion and tumor autonomy.

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Article

12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mice expressing epidermal-targeted v-fos induces rasHA-activated papillomas and carcinomas without p53 mutation: association of v-fos expression with promotion and tumor autonomy.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 May 1995

Greenhalgh D A, Wang X J, Eckhardt J N, Roop D R

Abstract excerpt

Transgenic mice that expressed v-fos exclusively in the epidermis by means of a human keratin K1-based targeting vector (HK1.fos) developed preneoplastic epidermal hyperplasia and hyperkeratosis after long latency and an associated wound promotion stimulus. To assess the requirements for papilloma formation and malignant conversion and determine the sensitivity to a chemical promotion stimulus, HK1.fos mice were...

Topics

Animals
Base Sequence
Biomarkers
Carcinoma
Cell Differentiation
Cell Transformation, Neoplastic
DNA, Neoplasm
Epidermis
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, fos

Genes, p53

Genes, ras

Hyperplasia

Keratins

Keratosis

Mice

Mice, Transgenic

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7544154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7544154-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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