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Article

Dynamics of bacterial phenotype selection in a colonized host.

Proceedings of the National Academy of Sciences of the United States of America - 5 Mar 2002

Webb G F, Blaser M J

Abstract excerpt

The population dynamics of Helicobacter pylori during colonization in an infected animal host provide a quantifiable experimental model of in vivo microbial phenotype evolution. Phenotype variability in H. pylori populations can be typed as polymorphic expression of Lewis antigens on their cell surfaces. The high mutational frequency of H. pylori for Lewis expression provides substrate for differential selection...

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Identifiers

PMID: 11867714
DOI: 10.1073/pnas.042685799
PMCID: PMC122485

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