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Article

Correlation versus causation: Helicobacter pylori population heterogeneity complicates the identification of mutant strain phenotypes.

mSphere - 27 Jan 2026

Wylie Marina R, Gilbreath Jeremy J, Melton-Celsa Angela, Merrell D Scott

Abstract excerpt

Helicobacter pylori causes cancer in approximately 1% of infected individuals. A proposed mechanism of H. pylori persistence centers on the ability of the pathogen to form biofilms, yet little is known about specific genetic requirements for this process. Our investigation revealed that during lab passage, H. pylori accumulates genetic changes that impact further phenotypic analyses. Specifically, we first sought...

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Identifiers

PMID: 41395945
DOI: 10.1128/msphere.00638-25
PMCID: PMC12838425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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