Comparison of genetic divergence and fitness between two subclones of Helicobacter pylori.

doi:10.1128/IAI.69.12.7832-7838.2001

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Article

Comparison of genetic divergence and fitness between two subclones of Helicobacter pylori.

Infection and immunity - 1 Dec 2001

Björkholm B, Lundin A, Sillén A, Guillemin K, Salama N, Rubio C, Gordon J I, Falk P, Engstrand L

Abstract excerpt

Helicobacter pylori has a very plastic genome, reflecting its high rate of recombination and point mutation. This plasticity promotes divergence of the population by the development of subclones and presumably enhances adaptation to host niches. We have investigated the genotypic and phenotypic characteristics of two such subclones isolated from one patient as well as the genetic evolution of these isolates...

Topics

Adhesins, Bacterial
Animals
Antigens, Bacterial
Bacterial Proteins
Clone Cells
Flagellin
Genes, rRNA
Genotype
Germ-Free Life
Helicobacter Infections
Helicobacter pylori
Humans
Lewis Blood Group Antigens
Mice

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Oligonucleotide Array Sequence Analysis

Oligosaccharides

RNA, Ribosomal, 16S

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Identifiers

PMID: 11705965
DOI: 10.1128/IAI.69.12.7832-7838.2001
PMCID: PMC98879

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