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Article

Horizontal gene transfer potentiates adaptation by reducing selective constraints on the spread of genetic variation.

Proceedings of the National Academy of Sciences of the United States of America - 27 Oct 2020

Woods Laura C, Gorrell Rebecca J, Taylor Frank, Connallon Tim, Kwok Terry, McDonald Michael J

Abstract excerpt

Horizontal gene transfer (HGT) confers the rapid acquisition of novel traits and is pervasive throughout microbial evolution. Despite the central role of HGT, the evolutionary forces that drive the dynamics of HGT alleles in evolving populations are poorly understood. Here, we show that HGT alters the evolutionary dynamics of genetic variation, so that deleterious genetic variants, including antibiotic resistance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33055207
DOI: 10.1073/pnas.2005331117
PMCID: PMC7604491

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