Article
A mutation burst during the acute phase of Helicobacter pylori infection in humans and rhesus macaques.
Nature communications - 13 Jun 2014
Linz Bodo, Windsor Helen M, McGraw John J, Hansen Lori M, Gajewski John P, Tomsho Lynn P, Hake Caylie M, Solnick Jay V, Schuster Stephan C, Marshall Barry J
Abstract excerpt
The evolution rate and genetic changes that occur during chronic infection with Helicobacter pylori have been analysed, but little is known about the genomic changes during the initial, acute bacterial infection phase. Here we analyse the rate and pattern of genome evolution in H. pylori from the genomes of two input strains isolated from human volunteers with asymptomatic infection, and the genomes of two output...
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