Article
PPARalpha gene variation and physical performance in Russian athletes.
European journal of applied physiology - 1 May 2006
Ahmetov Ildus I, Mozhayskaya Irina A, Flavell David M, Astratenkova Irina V, Komkova Antonina I, Lyubaeva Ekaterina V, Tarakin Pavel P, Shenkman Boris S, Vdovina Anastasia B, Netreba Aleksei I, Popov Daniil V, Vinogradova Olga L, Montgomery Hugh E, Rogozkin Viktor A
Abstract excerpt
Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates genes responsible for skeletal and heart muscle fatty acid oxidation. Previous studies have shown that the PPARalpha intron 7 G/C polymorphism was associated with left ventricular growth in response to exercise. We speculated that GG homozygotes should be more prevalent within a group of endurance-oriented athletes, have normal fatty acid...
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