Article
Polymorphisms of the peroxisome proliferator-activated receptor-gamma coactivator-1alpha gene are associated with hypertrophic cardiomyopathy and not with hypertension hypertrophy.
Clinical chemistry and laboratory medicine - 1 Jan 2007
Wang Shuxia, Fu Chunyan, Wang Hu, Shi Yi, Xu Xiqi, Chen Jingzhou, Song Xiaodong, Sun Kai, Wang Jianwei, Fan Xiaohan, Wang Hongjian, Yang Xiaomin, Huan Tujun, Hui Rutai
Abstract excerpt
BACKGROUND: The clinical phenotype of both hypertrophic cardiomyopathy (HCM) and left ventricular hypertrophy (LVH) induced by hypertension is heterogeneous. Genetic factors may contribute to this heterogeneity. Evidence is accumulating that the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) gene plays a role in cardiac hypertrophy. The aim of our study was to identify the...
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