Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 1999

Drotschmann K, Clark A B, Tran H T, Resnick M A, Gordenin D A, Kunkel T A

Abstract excerpt

Heterozygosity for germ-line mutations in the DNA mismatch repair gene MSH2 predisposes humans to cancer. Here we use a highly sensitive reporter to describe a spontaneous mutator phenotype in diploid yeast cells containing a deletion of only one MSH2 allele. We also identify five MSH2 missense mutations that have dominant mutator effects in heterozygous cells when expressed at normal levels from the natural MSH2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pair Mismatch
Share to DNA, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to Fungal Proteins

Share to Gene Expression Regulation, Fungal

Share to Genes, Fungal

Share to MutS Homolog 2 Protein

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 10077621
DOI: 10.1073/pnas.96.6.2970
PMCID: PMC15879

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene.PMID 10077621Read ↗

Mutator phenotype due to loss of heterozygosity in diploid yeast strains with mutations in MSH2 and MLH1.Semantic proximity Read ↗

Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function.Semantic proximity Read ↗

Mutator phenotypes of common polymorphisms and missense mutations in MSH2.Semantic proximity Read ↗

Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination.Semantic proximity Read ↗

Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.Semantic proximity Read ↗

Mutation rates, spectra, and genome-wide distribution of spontaneous mutations in mismatch repair deficient yeast.Semantic proximity Read ↗

MSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instability.Semantic proximity Read ↗

Functional analysis of human MutSalpha and MutSbeta complexes in yeast.Semantic proximity Read ↗

EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae.Semantic proximity Read ↗

Genomic Instability Promoted by Overexpression of Mismatch Repair Factors in Yeast: A Model for Understanding Cancer ProgressionSemantic proximity Read ↗

Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.