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Article

Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase.

The Journal of biological chemistry - 10 May 2002

Bowler Russell P, Nicks Mike, Olsen Dorte Aa, Thøgersen Ida B, Valnickova Zuzana, Højrup Peter, Franzusoff Alex, Enghild Jan J, Crapo James D

Abstract excerpt

Extracellular superoxide dismutase (EC-SOD) is an antioxidant enzyme that attenuates brain and lung injury from oxidative stress. A polybasic region in the carboxyl terminus distinguishes EC-SOD from other superoxide dismutases and determines EC-SOD's tissue half-life and affinity for heparin. There are two types of EC-SOD that differ based on the presence or absence of this heparin-binding region. It has...

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PMID: 11861638
DOI: 10.1074/jbc.M105409200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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