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Article

A site-directed mutant of Cu,Zn-superoxide dismutase modeled after native extracellular superoxide dismutase.

Biological trace element research - 1 Jan 1995

Gao B, Flores S C, McCord J M

Abstract excerpt

The well-studied cytosolic Cu,Zn-superoxide dismutase (SOD) protects against reperfusion injury, although its short (6 min) plasma half-life and negative charge create undesirable pharmacokinetics. We have designed, cloned, and expressed a genetic variant of SOD with altered pharmacological properties. A fusion gene consisting of the entire coding region of human SOD followed by a positively charged...

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Identifiers

PMID: 7779581
DOI: 10.1007/BF02790105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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