10-fold increase in human plasma extracellular superoxide dismutase content caused by a mutation in heparin-binding domain.

Article

10-fold increase in human plasma extracellular superoxide dismutase content caused by a mutation in heparin-binding domain.

The Journal of biological chemistry - 22 Jul 1994

Sandström J, Nilsson P, Karlsson K, Marklund S L

Abstract excerpt

Extracellular superoxide dismutase (EC-SOD) is a secretory SOD isoenzyme. 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium. Analysis of EC-SOD in plasma samples from 50...

Topics

Amino Acid Sequence
Base Sequence
Cell Compartmentation
Extracellular Space
Heparin
Humans
Molecular Sequence Data
Mutation
Protein Binding
Superoxide Dismutase

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