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Article

The intracellular proteolytic processing of extracellular superoxide dismutase (EC-SOD) is a two-step event.

The Journal of biological chemistry - 21 May 2004

Olsen Dorte Aa, Petersen Steen V, Oury Tim D, Valnickova Zuzana, Thøgersen Ida B, Kristensen Torsten, Bowler Russel P, Crapo James D, Enghild Jan J

Abstract excerpt

Extracellular superoxide dismutase (EC-SOD) is a tetramer composed of either intact (Trp(1)-Ala(222)) or proteolytically cleaved (Trp(1)-Glu(209)) subunits. The latter form is processed intracellularly before secretion and lacks the C-terminal extracellular matrix (ECM)-binding region ((210)RKKRR...

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Identifiers

PMID: 15044467
DOI: 10.1074/jbc.M401180200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15044467-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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