Article
The cellular distribution of extracellular superoxide dismutase in macrophages is altered by cellular activation but unaffected by the naturally occurring R213G substitution.
Free radical biology & medicine - 1 Apr 2014
Gottfredsen Randi H, Goldstrohm David A, Hartney John M, Larsen Ulrike G, Bowler Russell P, Petersen Steen V
Abstract excerpt
Extracellular superoxide dismutase (EC-SOD) is responsible for the dismutation of the superoxide radical produced in the extracellular space and known to be expressed by inflammatory cells, including macrophages and neutrophils. Here we show that EC-SOD is produced by resting macrophages and associated with the cell surface via the extracellular matrix (ECM)-binding region. Upon cellular activation induced by...
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