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Article

An Update on Overcoming MDR1-Mediated Multidrug Resistance in Cancer Chemotherapy

27 Dec 2005

Abstract excerpt

The intrinsic or acquired resistance to anticancer drugs remains one of the most significant factors impeding the progress of cancer chemotherapy. This phenomenon often involves simultaneous resistance to other anticancer drugs that differ in their chemical structure and mode of action and are not even used in chemotherapy. This phenotype has been called multidrug resistance (MDR). Although the cellular basis...

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PMID: 16454744
DOI: 10.2174/138161206775201965

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