Article
Sequence gamma 377-395(P2), but not gamma 190-202(P1), is the binding site for the alpha MI-domain of integrin alpha M beta 2 in the gamma C-domain of fibrinogen.
Biochemistry - 12 Aug 2003
Ugarova Tatiana P, Lishko Valeryi K, Podolnikova Nataly P, Okumura Nobuo, Merkulov Sergei M, Yakubenko Valentin P, Yee Vivien C, Lord Susan T, Haas Thomas A
Abstract excerpt
The interaction between the leukocyte integrin alpha(M)beta(2) (CD11b/CD18, Mac-1, CR3) and fibrinogen mediates the recruitment of phagocytes during the inflammatory response. Previous studies demonstrated that peptides P2 and P1, duplicating gamma 377-395 and gamma 190-202 sequences in the gamma C domain of fibrinogen, respectively, blocked the fibrinogen-binding function of alpha(M)beta(2), implicating these...
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