Article
Beta 2 (CD18) mutations abolish ligand recognition by I domain integrins LFA-1 (alpha L beta 2, CD11a/CD18) and MAC-1 (alpha M beta 2, CD11b/CD18).
The Journal of biological chemistry - 6 Jan 1995
Bajt M L, Goodman T, McGuire S L
Abstract excerpt
The "I" domains of the beta 2 (CD18) leukocyte integrins are implicated in ligand binding function. Moreover, rather than recognizing linear peptide sequences, this class of integrins generally recognizes multiple discontinuous sites on immunoglobulin superfamily adhesion receptors. A conserved c...
Topics
- Amino Acid Sequence
- Aspartic Acid
- Cells, Cultured
- Humans
- Integrins
- Lymphocyte Function-Associated Antigen-1
- Macrophage-1 Antigen
- Molecular Sequence Data
- Mutation
- Sequence Alignment
- Serine