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Article

Aspartate 698 within a novel cation binding motif in alpha 4 integrin is required for cell adhesion.

The Journal of biological chemistry - 4 Aug 1995

Ma L, Conrad P J, Webb D L, Blue M L

Abstract excerpt

The interactions of alpha 4 beta 1 integrin with vascular cell adhesion molecule (VCAM) and fibronectin play important roles in many physiological and pathological processes. To understand the mechanism of alpha 4 beta 1 integrin-mediated cell adhesion, we made mutant alpha 4 constructs. Three aspartic acid (Asp) residues in alpha 4, Asp-489, Asp-698, and Asp-811, were replaced with glutamic acids (Glu). The...

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Identifiers

PMID: 7629165
DOI: 10.1074/jbc.270.31.18401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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