Article
Aspartate 698 within a novel cation binding motif in alpha 4 integrin is required for cell adhesion.
The Journal of biological chemistry - 4 Aug 1995
Ma L, Conrad P J, Webb D L, Blue M L
Abstract excerpt
The interactions of alpha 4 beta 1 integrin with vascular cell adhesion molecule (VCAM) and fibronectin play important roles in many physiological and pathological processes. To understand the mechanism of alpha 4 beta 1 integrin-mediated cell adhesion, we made mutant alpha 4 constructs. Three as...
Topics
- Amino Acid Sequence
- Antigens, CD
- Aspartic Acid
- Binding Sites
- Blotting, Western
- Cations
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Line
- DNA Mutational Analysis
- Integrin alpha4
- Integrin alpha4beta1
- Integrins
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Precipitin Tests
- Protein Binding