Article
The biology and medicinal chemistry of epothilones.
Current medicinal chemistry. Anti-cancer agents - 1 Jan 2002
Wartmann M, Altmann K-H
Abstract excerpt
Epothilones are naturally occurring 16-membered macrolides with the ability to promote tubulin polymerization in vitro and to stabilize preformed microtubules against Ca(2+)- or cold-induced depolymerization. At the cellular level, interference with microtubule functionality results in potent inhibition of cancer cell proliferation at nM to even sub-nM concentrations. Most significantly, epothilones, unlike...
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