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Article

Complement deficiency ameliorates collagen-induced arthritis in mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2002

Hietala Max Albert, Jonsson Ing-Marie, Tarkowski Andrej, Kleinau Sandra, Pekna Marcela

Abstract excerpt

Collagen-induced arthritis (CIA) is an experimental animal model of human rheumatoid arthritis being characterized by synovitis and progressive destruction of cartilage and bone. CIA is induced by injection of heterologous or homologous collagen type II in a susceptible murine strain. DBA/1J mice deficient of complement factors C3 (C3(-/-)) and factor B (FB(-/-)) were generated to elucidate the role of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12077276
DOI: 10.4049/jimmunol.169.1.454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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