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Article

A Codominant Role of FcγRI/III and C5aR in the Reverse Arthus Reaction

1 Jan 2000

Abstract excerpt

Recent attempts to specify the relative contribution of FcR and complement in various experimental systems of immune complex disease have led to opposing conclusions. As concluded in IgG FcRgamma-/- mice, manifestation of disease is almost exclusively determined by FcgammaR on effector cells, arguing for a minor role of complement. In contrast, data obtained with C5aR-/- mice suggested that, dependent on the...

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PMID: 10623857
DOI: 10.4049/jimmunol.164.2.1065

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