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Article

Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris.

Archives of dermatological research - 1 Oct 2002

Shimizu Atsushi, Ishiko Akira, Ota Takayuki, Tsunoda Kazuyuki, Koyasu Shigeo, Amagai Masayuki, Nishikawa Takeji

Abstract excerpt

Pemphigus vulgaris (PV) is an autoimmune blistering disease caused by autoantibodies against the desmosomal cadherins, desmogleins 1 and 3 (Dsg1, Dsg3) of which Dsg3 plays a major pathogenic role. We have previously generated a novel active disease mouse model for PV, which was produced by the transfer of splenocytes from Dsg3(-/-) mice, immunized with recombinant mouse Dsg3, into Rag2(-/-)-immunodeficient mice...

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Antibodies
Antibody Formation
Cadherins
Fluorescent Antibody Technique
Hair Follicle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Electron

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PMID: 12373337
DOI: 10.1007/s00403-002-0341-z

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Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris.PMID 12373337Read ↗

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