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Article

Modeling spinal muscular atrophy in Drosophila.

PloS one - 15 Sept 2008

Chang Howard Chia-Hao, Dimlich Douglas N, Yokokura Takakazu, Mukherjee Ashim, Kankel Mark W, Sen Anindya, Sridhar Vasanthi, Fulga Tudor A, Hart Anne C, Van Vactor David, Artavanis-Tsakonas Spyros

Abstract excerpt

Spinal Muscular Atrophy (SMA), a recessive hereditary neurodegenerative disease in humans, has been linked to mutations in the survival motor neuron (SMN) gene. SMA patients display early onset lethality coupled with motor neuron loss and skeletal muscle atrophy. We used Drosophila, which encodes a single SMN ortholog, survival motor neuron (Smn), to model SMA, since reduction of Smn function leads to defects...

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Identifiers

PMID: 18791638
DOI: 10.1371/journal.pone.0003209
PMCID: PMC2527655

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Source receipt: pubmed, retrieved 7 Sept 2026.

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