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Article

Genetic traits and diet triggering the iron-induced hepatic model of the idiopathic disorder sporadic porphyria cutanea tarda.

Free radical biology & medicine - 16 Mar 2026

Robinson Susan, Davies Reginald, Vagany Viktoria, Gant Timothy W, Smith Andrew G

Abstract excerpt

Metabolic disorders can be the consequence of external factors and individual susceptibility. Sporadic porphyria cutanea tarda (sPCT) is an idiopathic disorder of liver heme synthesis exhibiting inhibition of uroporphyrinogen decarboxylase, characterised by dermal and hepatic deposition of uroporphyrins from oxidation of sensitive uroporphyrinogens (uroporphyria). sPCT is associated with alcohol, estrogenic...

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PMID: 41539024
DOI: 10.1016/j.freeradbiomed.2025.12.049

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F2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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