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Article

Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2.

Toxicology and applied pharmacology - 1 Jun 2007

Gorman Nadia, Trask Heidi S, Robinson Susan W, Sinclair Jacqueline F, Gerhard Glenn S, Smith Andrew G, Sinclair Peter R

Abstract excerpt

Hexachlorobenzene (HCB), a weak ligand of the aryl hydrocarbon receptor (AHR), causes hepatic uroporphyrin (URO) accumulation (uroporphyria) in humans and animals. CYP1A2 has been shown to be necessary in the development of uroporphyria in mice. Using mice expressing the low affinity form of the...

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Share to Cytochrome P-450 CYP1A2
Share to Hemochromatosis Protein
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Mice, Inbred C57BL

Share to Porphyrias

Share to Receptors, Aryl Hydrocarbon

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Source

Identifiers

PMID: 17466352
DOI: 10.1016/j.taap.2007.03.007

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17466352-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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