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ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question

1 Jan 2013

Abstract excerpt

The major Mycobacterium tuberculosis virulence factor ESAT-6 exported by the ESX-1 secretion system has been described as a pro-apoptotic factor by several independent groups in recent years, sustaining a role for apoptosis in M. tuberculosis pathogenesis. This role has been supported by independent studies in which apoptosis has been shown as a hallmark feature in human and mouse lungs infected with virulent...

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PMID: 24364000
DOI: 10.3389/fcimb.2013.00088

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