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Article

Dissection of the energetic coupling across the Src SH2 domain-tyrosyl phosphopeptide interface.

Journal of molecular biology - 15 Feb 2002

Lubman Olga Y, Waksman Gabriel

Abstract excerpt

Src Homology (SH2) domains play critical roles in signaling pathways by binding to phosphotyrosine (pTyr)-containing sequences, thereby recruiting SH2 domain-containing proteins to tyrosine-phosphorylated sites on receptor molecules. Investigations of the peptide binding specificity of the SH2 domain of the Src kinase (Src SH2 domain) have defined the EEI motif C-terminal to the phosphotyrosine as the...

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Identifiers

PMID: 11851339
DOI: 10.1006/jmbi.2001.5362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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