Article
A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function.
Molecular cell - 16 Jan 2009
Barouch-Bentov Rina, Che Jianwei, Lee Christian C, Yang Yating, Herman Ann, Jia Yong, Velentza Anastasia, Watson James, Sternberg Luise, Kim Sunjun, Ziaee Niusha, Miller Andrew, Jackson Carie, Fujimoto Manabu, Young Mike, Batalov Serge, Liu Yi, Warmuth Markus, Wiltshire Tim, Cooke Michael P, Sauer Karsten
Abstract excerpt
The glycine-rich G loop controls ATP binding and phosphate transfer in protein kinases. Here we show that the functions of Src family and Abl protein tyrosine kinases require an electrostatic interaction between oppositely charged amino acids within their G loops that is conserved in multiple other phylogenetically distinct protein kinases, from plants to humans. By limiting G loop flexibility, it controls ATP...
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