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Article

Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells.

Human molecular genetics - 15 Sept 2006

van Rossum Agnes G S H, Aartsen Wendy M, Meuleman Jan, Klooster Jan, Malysheva Anna, Versteeg Inge, Arsanto Jean-Pierre, Le Bivic André, Wijnholds Jan

Abstract excerpt

Mutations in the human Crumbs homologue-1 (CRB1) gene cause retinal diseases including Leber's congenital amaurosis (LCA) and retinitis pigmentosa type 12. The CRB1 transmembrane protein localizes at a subapical region (SAR) above intercellular adherens junctions between photoreceptor and Müller glia (MG) cells. We demonstrate that the Crb1-/- phenotype, as shown in Crb1-/- mice, is accelerated and intensified in...

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Source

Identifiers

PMID: 16885194
DOI: 10.1093/hmg/ddl194

Genes

CRB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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