Article
Drosophila crumbs is required to inhibit light-induced photoreceptor degeneration.
Current biology : CB - 1 Oct 2002
Johnson Kevin, Grawe Ferdi, Grzeschik Nicola, Knust Elisabeth
Abstract excerpt
Mutations in the human transmembrane protein CRB1 are associated with severe forms of retinal dystrophy, retinitis pigmentosa 12 (RP12), and Leber's congenital amaurosis (LCA). The Drosophila homolog, crumbs, is required for polarity and adhesion in embryonic epithelia and for correct formation of adherens junctions and proper morphogenesis of photoreceptor cells. Here, we show that mutations in Drosophila crumbs...
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