Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diverse functions and pathogenetic role of Crumbs in retinopathy.

Cell communication and signaling : CCS - 27 May 2024

Zhou Xuebin, Zhao Liangliang, Wang Chenguang, Sun Wei, Jia Bo, Li Dan, Fu Jinling

Abstract excerpt

The Crumbs protein (CRB) family plays a crucial role in maintaining the apical-basal polarity and integrity of embryonic epithelia. The family comprises different isoforms in different animals and possesses diverse structural, localization, and functional characteristics. Mutations in the human CRB1 or CRB2 gene may lead to a broad spectrum of retinal dystrophies. Various CRB-associated experimental models have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Eye Proteins
Share to Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Nerve Tissue Proteins

Share to Retina

Share to Retinal Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 38802833
DOI: 10.1186/s12964-024-01673-z
PMCID: PMC11129452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diverse functions and pathogenetic role of Crumbs in retinopathy.PMID 38802833Read ↗

Towards understanding CRUMBS function in retinal dystrophies.Semantic proximity Read ↗

CRUMBS-associated mutations in Retinitis Pigmentosa and its impact on molecular scaffolding.Semantic proximity Read ↗

The Enigma of CRB1 and CRB1 Retinopathies.Semantic proximity Read ↗

Crumbs homologue 1 in polarity and blindness.Semantic proximity Read ↗

Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs.Semantic proximity Read ↗

Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal laminationSemantic proximity Read ↗

Detailed Comparison Between Two Main Phenotypes of CRB1-Related Retinal Dystrophy, Pan-retinopathy and Maculopathy.Semantic proximity Read ↗

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.Semantic proximity Read ↗

Composition and function of the Crumbs protein complex in the mammalian retina.Semantic proximity Read ↗

CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila.Semantic proximity Read ↗

CRB1 mutation spectrum in inherited retinal dystrophies.Semantic proximity Read ↗

Drosophila crumbs is required to inhibit light-induced photoreceptor degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.