Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parameters driving the selection of nelfinavir-resistant human immunodeficiency virus type 1 variants.

Journal of virology - 1 Sept 2003

Perrin Virginie, Mammano Fabrizio

Abstract excerpt

We investigated the parameters driving nelfinavir resistance, along the D30N and L90M evolutionary pathways. The advantage of the D30N mutant was mostly due to its resistance level, while the L90M mutation allowed preservation of infectivity coupled with minimal resistance. Emergence of secondary mutations further increased the selective advantage of viruses harboring D30N.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Viral
Share to HIV-1
Share to HIV Protease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Protease Inhibitors

Share to Mutation

Share to Nelfinavir

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 12941931
DOI: 10.1128/jvi.77.18.10172-10175.2003
PMCID: PMC224578

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parameters driving the selection of nelfinavir-resistant human immunodeficiency virus type 1 variants.PMID 12941931Read ↗

Interference between D30N and L90M in selection and development of protease inhibitor-resistant human immunodeficiency virus type 1.Semantic proximity Read ↗

Selective-advantage profile of human immunodeficiency virus type 1 integrase mutants explains in vivo evolution of raltegravir resistance genotypes.Semantic proximity Read ↗

Alternative, age- and viral load-related routes of nelfinavir resistance in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy.Semantic proximity Read ↗

Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases.Semantic proximity Read ↗

The impact of the nelfinavir resistance-conferring mutation D30N on the susceptibility of HIV-1 subtype B to other protease inhibitors.Semantic proximity Read ↗

Mutation D30N is not preferentially selected by human immunodeficiency virus type 1 subtype C in the development of resistance to nelfinavir.Semantic proximity Read ↗

Distinct mutation pathways of non-subtype B HIV-1 during in vitro resistance selection with nonnucleoside reverse transcriptase inhibitors.Semantic proximity Read ↗

HIV-1 genotype resistance pattern and evolution in patients failing nelfinavir-containing regimens.Semantic proximity Read ↗

Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants.Semantic proximity Read ↗

New Insights into the In Silico Prediction of HIV Protease Resistance to NelfinavirSemantic proximity Read ↗

Understanding the HIV-1 protease nelfinavir resistance mutation D30N in subtypes B and C through molecular dynamics simulations.Semantic proximity Read ↗

Characterization of amino acids Arg, Ser and Thr at position 70 within HIV-1 reverse transcriptase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.