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Article

Multiple independent origins of a protease inhibitor resistance mutation in salvage therapy patients.

Retrovirology - 25 Jan 2008

Kapoor Amit, Shapiro Beth, Shafer Robert W, Shulman Nancy, Rhee Soo-Yon, Delwart Eric L

Abstract excerpt

BACKGROUND: Combination anti-viral therapies have reduced treatment failure rates by requiring multiple specific mutations to be selected on the same viral genome to impart high-level drug resistance. To determine if the common protease inhibitor resistance mutation L90M is only selected once or repeatedly on different HIV genetic backbones during the course of failed anti-viral therapies we analyzed a linked...

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Share to Anti-HIV Agents
Share to Drug Resistance, Multiple, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

Share to Genome, Viral

Share to HIV Protease

Share to HIV Protease Inhibitors

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Source

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Identifiers

PMID: 18221530
DOI: 10.1186/1742-4690-5-7
PMCID: PMC2265302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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