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Article

Radiosensitization of human glioma cells in vitro and in vivo with acyclovir and mutant HSV-TK75 expressed from adenovirus.

International journal of radiation oncology, biology, physics - 1 Mar 2002

Rosenberg Elizabeth, Hawkins William, Holmes Matthew, Amir Cyrus, Schmidt-Ullrich Rupert K, Lin Peck Sun, Valerie Kristoffer

Abstract excerpt

PURPOSE: We recently reported that an adenovirus-expressing mutant HSV-TK75 (AdCMV-TK75) radiosensitized rat syngeneic gliomas in combination with low concentrations of acyclovir (ACV) much more effectively than a virus expressing wild-type herpes simplex virus thymidine kinase (HSV-TK). In this report we have examined whether similar radiosensitizing effects are also seen with human glioma cells in vitro and in...

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Identifiers

PMID: 11849808
DOI: 10.1016/s0360-3016(01)02754-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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