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Article

Substantially improved in vivo radiosensitization of rat glioma with mutant HSV-TK and acyclovir.

Cancer gene therapy - 1 Jan 2001

Valerie K, Hawkins W, Farnsworth J, Schmidt-Ullrich R, Lin P S, Amir C, Feden J

Abstract excerpt

We recently demonstrated in vitro that a mutant HSV-TK (mutant 75) expressed from an adenovirus (AdCMV-TK75) radiosensitized rat RT2 glioma cells significantly better than wild type HSV-TK (AdCMV-TK) in combination with acyclovir (ACV). To examine whether a similar improvement could also be observed in vivo, we tested these viruses in a syngeneic rat glioma tumor model (RT2/Fischer 344). First, we demonstrate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11219491
DOI: 10.1038/sj.cgt.7700265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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