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Article

Clarifying the Risk of Lung Disease in SZ Alpha-1 Antitrypsin Deficiency.

American journal of respiratory and critical care medicine - 1 Jul 2020

Franciosi Alessandro N, Hobbs Brian D, McElvaney Oliver J, Molloy Kevin, Hersh Craig, Clarke Louise, Gunaratnam Cedric, Silverman Edwin K, Carroll Tomás P, McElvaney Noel G

Abstract excerpt

Rationale: The ZZ genotype of alpha-1 antitrypsin deficiency (AATD) is associated with chronic obstructive pulmonary disease (COPD), even among never-smokers. The SZ genotype is also considered severe; yet, its effect on lung health remains unclear.Objectives: To determine the effect of SZ-AATD on spirometry compared with a normal-risk population and to determine the effect of smoking cessation in this...

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Identifiers

PMID: 32197047
DOI: 10.1164/rccm.202002-0262OC
PMCID: PMC7530947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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